A diffuse intrinsic pontine glioma (DIPG) is a tumor located in the pons (middle) of the brain stem. The brain stem is the bottommost portion of the brain, connecting the cerebrum with the spinal cord. The majority of brain stem tumors occur in the pons and are diffusely infiltrating (they grow amidst the nerves), and therefore cannot be surgically removed. Glioma is a general name for any tumor that arises from the supportive tissue called glia, which help keep the neurons in place and functioning well. The brain stem contains all of the afferent (incoming) neurons within the spinal cord, as well as important structures involved in eye movements and in face and throat muscle control and sensation.

Source: Wikipedia.

DIPG Trials


Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers.

Abstracts and Publications

PLOS Phase 1 Published Paper

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/ Refractory Neuroblastoma. Download PDF.

Oncotarget LIN28/Let 7 Published Paper

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma. Download PDF.

ANR 2016 Abstract Book

DFMO maintains remission and increases overall survival in high risk neuroblastoma: results of a phase II prevention trial. PDF.