Valerie I. Brown, MD, PhD

Penn State Children’s Hospital

Dr. Brown is the Director of Experimental Therapeutics, Leader of the Experimental Therapeutics Research and Clinical Team (ExTRaCT), and Director of the Fellowship Program of the Division of Pediatric Hematology/Oncology, Department of Pediatrics at Penn State Children’s Hospital.

Appointments: (717) 531-3097 to schedule (Suzanne Treadway, research nurse coordinator).

Division of Pediatric Hematology/Oncology
500 University Drive
P.O. Box 850
Hershey, PA 17033-0850

Phone: (717) 531-3097 (research nurse coordinator)

E-mail: streadway@pennstatehealth.psu.edu (research nurse coordinator)

Dr. Brown is a Pediatric Oncologist and Hematopoietic Stem Cell Transplantation (HSCT) Specialist at Penn State Health Children’s Hospital located in Hershey, PA. Currently, she is the Director of Experimental Therapeutics and Leader of the Experimental Therapeutics Research and Clinical Team (ExTRaCT) in the division of Pediatric Hematology/Oncology. The Experimental Therapeutics Program and ExTRaCT are supported by Four Diamonds, THON and Mini-THON. She is Associate Professor of Pediatrics at Penn State College of Medicine. She is also the Director of the Pediatric Hematology/Oncology Fellowship Program. The infrastructure within the Division of Pediatric Hematology/Oncology at Penn State Children’s Hospital provides comprehensive care to infants, children, adolescents and young adults using a multidisciplinary team approach with patients and their families being at the center of the healthcare team. This team extends beyond Pediatric Hematology/Oncology including the expertise of many other pediatric specialists at Penn State Children’s Hospital and at Penn State Cancer Institute, resulting in a cohesive network to meet the needs of all of our patients and their families. In addition to the outstanding clinical care enterprise, our basic science and translational laboratory research endeavors are thriving within our division as well as on the Penn State Health Medical Center campus at large. All of these resources and efforts together create an outstanding environment in which innovative therapies can be translated directly to the patient’s bedside.

Dr. Brown has had a long-standing professional interest in discovering new strategies to treat childhood cancer that include biologically-relevant approaches with the goal of maximizing cure rates while minimizing short- and long-term toxicities. Early on, she developed an expertise in understanding the “deranged network wiring” within a leukemia cell sustained its growth and survival and then how best to “short circuit” the leukemia cell such that it is no longer viable or, at least, more vulnerable to conventional chemotherapy. This early work contributed to the development of novel, biologically- targeted treatment strategies for acute lymphoblastic leukemia. Since then, Dr. Brown’s scientific interests have transitioned more towards the design and testing of innovative approaches that incorporate molecularly targeted agents either to the tumor itself or its microenvironment for the treatment of pediatric cancers. Because of her extensive experience in translating pre-clinical, scientific observations into feasible regimens, Dr. Brown is able to make significant contributions to collaborative teams, such as Beat Childhood Cancer, in order to deliver innovative, effective treatments more efficiently to childhood cancer patients.

Sept. 1987 – Dec. 1992

Perelman School of Medicine at the University of Pennsylvania (formerly University of Pennsylvania School of Medicine), Philadelphia, PA

Doctor of Philosophy in Immunology

Sept 1992 – May 1996

Perelman School of Medicine at the University of Pennsylvania (formerly University of Pennsylvania School of Medicine), Philadelphia, PA Pediatric

Doctor of Medicine

July 1996- June 1999

The Children’s Hospital of Philadelphia, Philadelphia, PA

Residency Program in General Pediatrics

July 1999- June 2002

The Children’s Hospital of Philadelphia, Philadelphia, PA

Pediatric Hematology/Oncology Fellowship