Medulloblastoma

Medulloblastoma is a type of brain tumor. A brain tumor begins when healthy cells in the brain change and grow out of control, forming a mass. A tumor can be cancerous or benign. A cancerous tumor is malignant, meaning it can grow and spread to other parts of the body. A benign tumor means the tumor can grow but will not spread.

The brain and spinal column make up the central nervous system (CNS), where all vital functions are controlled, including thought, speech, and body strength. Medulloblastoma begins in different cells in the cerebellum, which is the back of the brain. The cerebellum controls body movement and coordination.

Source: cancer.net.

Relevant Videos

Medulloblastoma Trials

ONC-403-001

A Two-Part Study of TB-403 in Pediatric Subjects With Relapsed or Refractory Medulloblastoma
OPEN

NMTRC009

Molecular-guided therapy for the treatment of patients with relapsed and refractory childhood cancers
OPEN

V0706

A Phase II Trial of Nifurtimox for Refractory or Relapsed Neuroblastoma or Medulloblastoma
OPEN TO THE FOLLOWING GROUPS: RELAPSE NEUROBLASTOMA MEDULLOBLASTOMA

NMTRC008

A Feasibility Trial using Molecular-Guided Therapy for the Treatment of Patients with Relapsed and Refractory Childhood Cancer
CLOSED

TPI-287-11

A Phase 1 Trial of TPI 287 as a Single Agent and in Combination with Temozolomide in Patients with Refractory or Recurrent Neuroblastoma or Medulloblastoma
CLOSED

NMTRC004

A Phase I/II Trial of TPI 287 in Patients with Refractory or Recurrent Neuroblastoma and Medulloblastoma
CLOSED

Abstracts and Publications

PLOS Phase 1 Published Paper

A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/ Refractory Neuroblastoma. Download PDF.

Oncotarget LIN28/Let 7 Published Paper

Targeting ornithine decarboxylase reverses the LIN28/Let-7 axis and inhibits glycolytic metabolism in neuroblastoma. Download PDF.

ANR 2016 Abstract Book

DFMO maintains remission and increases overall survival in high risk neuroblastoma: results of a phase II prevention trial. PDF.